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The Platelet Supply Problem

Limited platelet supply and increasing demand are putting patients and hospitals at risk1,2

On average, 7,000 platelet transfusions are administered each day in the US.3 Oftentimes, hospitals struggle to meet this demand for platelets. Meanwhile, our rapidly aging population and enhanced transfusion safety requirements put a further strain on the available platelet supply.1,4

Without a safe, reliable source of platelets, some hospitals must postpone transfusions and surgeries, putting their patients at risk.2

STS is committed to helping meet the nation’s platelet needs with an innovative approach that taps an expanded, younger pool of prescreened donors to ensure a safe, consistent supply of platelets

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The demand for platelets is projected to rise with a rapidly aging population1,5

Patients 50 years and older receive 81% of platelet transfusions in the US1

100% 81% 0%

The demand for platelets will only continue to grow1

By 2030, the population 65 years and older will increase by almost 18 million people5,6

2021 2030 POPULATION 65+ YEARS IN MILLIONS = 1 MILLION PEOPLE

The growing demand for platelets is outpacing the available supply.1

From 2017 to 2019 demand continued to grow7

Apheresis platelet transfusions increased 8% Total platelet transfusions increased by 15.8%

Demand is challenging supply as the donor base ages8

Age Brackets Percentage platelet contribution 22.00% 20.00% 18.00% 16.00% 14.00% 12.00% 2001 2005 2010 2015 2020 10.00% 8.00% 6.00% 4.00% 2.00% 0.00% 16-18 19-22 23-25 26-30 31-35 36-40 41-45 46-50 51-55 56-60 61-65 66-70 71+

Adapted from Sayers, M. Donor motivation and psychosocial research. Transfusion. 2022;1-5. doi:10.1111/trf.17024. https://onlinelibrary.wiley.com/doi/epdf/10.1111/trf.17024

Largest donor cohort most likely to donate8

61-65 years 2020 41-45 years 2001

Federal mandates may constrain platelet availability even more4

The safety of platelet transfusions is critical, and the recent US Food and Drug Administration (FDA) mandate requires bacterial risk mitigation strategies such as large volume delayed sampling or pathogen reduction. Processing requirements associated with these bacterial risk mitigation strategies may further erode the platelet supply.

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Limited supply of regulatory compliant platelets impacts patients and hospitals2

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Of high transfusion volume hospitals surveyed, 47.2% reported supply challenges once or more a month.2
Infections, collections, & timing impact donations
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Current US Food and Drug Administration (FDA) mandates on bacterial risk mitigation will have a significant impact on the available supply of apheresis platelets4

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It takes approximately 3 hours to collect platelets, a time commitment that further limits the donor pool9

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A limited shelf life challenges the nation’s 1,805 rural hospitals to maintain a meaningful supply of platelets10,11